| 产品详情 |
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| Antigenic Specificity | GSK3B |
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| Clone | monoclonal |
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| Host Species | Mouse |
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| Reactive Species | human, mouse, monkey, rat |
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| Isotype | IgG2a |
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| Format | ascites |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | ELISA, WB, IHC, IF/ICC, FCM. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Glycogen synthase kinase 3 (GSK-3), a serine-threonine kinase with two isoforms (alpha and beta), was originally discovered as a key enzyme in glycogen metabolism. GSK-3 was subsequently shown to function in cell division, proliferation, motility and survival. GSK-3 plays a role in a number of pathological conditions including cancer and diabetes and is increasingly seen as an important component of neurological diseases. GSK-3 phosphorylates tau and presenilin-1, which are involved in the development of Alzheimer's disease. Both isoforms of GSK-3 are ubiquitously expressed, although particularly high levels of GSK-3 beta are found in the brain where it is involved in synaptic plasticity, possibly via regulation of NMDA receptor trafficking. GSK-3 phosphorylates over 40 different substrates including signaling proteins, transcription factors and structural proteins, and is part of the signal transduction cascade of a large number of growth factors and cytokines. The activity of GSK is regulated by phosphorylation (Akt: Akt-mediated phosphorylation at Ser21 of GSK-3 alpha and Ser9 of GSK-3 beta, S6K, RSK, PKA and PKC), dephosphorylation (PP1 and PP2A), and by binding to protein complexes (with beta catenin, axin, CK1 and the APC complex). |
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| Immunogen | Purified recombinant fragment of human GSK3B expressed in E. Coli.;. |
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| Other Names | glycogen synthase kinase 3 beta; Glycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3B; GSK3B; GSK3β; GSK-3beta; GSK3-beta |
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| Gene, Accession # | Gene ID: 2932, SwissProt: P49841 |
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| Catalog # | abx010856 |
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| Price | |
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| Order / More Info | GSK3B Antibody from ABBEXA |
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| Product Specific References | n/a |
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