| 产品详情 |
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| Product Name | E7449 |
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| Description | An inhibitor of PARP1, PARP2, and TNKS1/2 (IC50s = 1, 1.2, and 50-11 nM, respectively); selective for PARP1, PARP2, and TNKS1/2 over PARP3 and PARP6-15 (IC50s = >3 µM); inhibits growth of DT40 cells in a PARP-dependent manner (IC50s = 3.2 and >15 µM for wild-type and PARP-/- cells, respectively); decreases expression of Wnt/β-catenin signaling pathway proteins in SW480 cells; enhances antitumor activity of temozolomide and carboplatin in a B16/F10 isograft model and MX-1 mouse xenograft model, respectively; inhibits tumor growth in a BRCA1 mutant MDA-MB-436 breast cancer mouse xenograft model at 30 and 100 mg/kg per day; delays hair regrowth in mice following hair removal, |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | E-7449 PARP-1 2 3 6 PARP15 TNKS-1 TNKS2 DT-40 SW-480 B-16 F-10 MX1 BRCA-1 axin-2 MDAMB-436 anti-tumor NCIH460 MDAMB436 |
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| Gene, Accession, CAS # | CAS: 1140964-99-3 |
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| Catalog # | 21658-10 |
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| Price | |
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| Order / More Info | E7449 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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