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| Antigenic Specificity | Nucleocapsid Protein (aa 50-100) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | influenza a virus |
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| Isotype | n/a |
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| Format | serum |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (IHC),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Function: Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus. Subcellular location: Virion. Host nucleus. |
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| Immunogen | A synthetic peptide from aa region 50-100 of Influenza A virus Nucleocapsid protein conjugated to blue carrier protein was used as the antigen. |
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| Other Names | Nucleoprotein, Protein N, NP |
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| Gene, Accession # | n/a |
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| Catalog # | ABIN1841887 |
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| Price | |
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| Order / More Info | Nucleocapsid Protein (aa 50-100) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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