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| Antigenic Specificity | Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1) (aa 503-516), (C-Term) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | immunogen affinity purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunocytochemistry (ICC),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | HSP60 is a member of the chaperonin class of protein factors, which include the Escherichia coli groEL protein and the Rubisco subunit-binding protein of chloroplasts. It acts as a costimulator of human regulatory CD4-positive/CD25 -positive T cells, which inhibit lymphoproliferation and IFNG and TNF secretion by CD4-positive and CD8-positive T cells. HSP60 enhances Treg activity via TLR2, leading to activation of an intracellular signaling cascade that included p38, as well as inhibition of ERK phosphorylation. Suppression of target T cells is mediated by both cell-to-cell contact and by secretion of TGFB and IL10, and it leads to downregulation of ERK, NFKB, and TBET expression. The self-molecule HSP60 can downregulate adaptive immune responses by upregulating Tregs through TLR2 signaling. |
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| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of rat HSP60(503-516aa YDAMLGDFVNMVEK), different from the related human sequence by one amino acid. |
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| Other Names | 12|BP5|CG12101|Cpn60|Dmel\\CG12101|Dmhsp60|G62|HSP60|HSP60A|Hsp60A|IEF16|Mmp-P1|SSP 7506|cpn60|d-hsp60|hsp60|hsp60A|l(1)10Ac|l(1)BP5|l(1)G8|l(1)HM21|l(1)L12|l(1)dp025|HSPD1|hld4|groel|hsp65|spg13|chaperonin|CPN60|MIF4|MNA2|mopA|groL|crpA|cb863|fa04a05|fb22d10|fi27b05|id:ibd2197|sb:cb144|wu:fa04a05|wu:fb22d10|wu:fi04a12|wu:fi27b05|GROEL|HLD4|HSP-60|HSP65|HuCHA60|SPG13|60kDa|Hsp60|Hspd1-30p |
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| Gene, Accession # | Gene ID: 3329,15510,63868 |
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| Catalog # | ABIN343420 |
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| Price | |
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| Order / More Info | Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1) (aa 503-516), (C-Term) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 22500017, 2645524, 16767222 |
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