产品名称 Neurofilament, Heavy Polypeptide (NEFH) Antibody from ANTIBODIES-ONLINE GmbH
产品货号 ABIN335259
产品价格 现货询价,电话:010-67529703
产品规格 1 mL
产品品牌 ANTIBODIES-ONLINE GmbH
产品概述
产品详情
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Antigenic SpecificityNeurofilament, Heavy Polypeptide (NEFH)
CloneRNF405
Host SpeciesMouse
Reactive Specieshuman, rabbit, rat, dog, chicken, mouse, hamster, cow, monkey, guinea pig, sheep, Xenopus laevis, zebrafish
IsotypeIgG2a
Formatsupernatant
Size1 mL
Concentrationn/a
ApplicationsImmunohistochemistry (IHC),Immunohistochemistry (Frozen Sections) (IHC (fro)),Western Blotting (WB)
Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
DescriptionLike most other intermediate filament proteins (IFPs), the expression of the different neuronal IFPs is both tissue-specific and developmentally regulated. The neurofilament (NF) triplet proteins (70, 160, and 200 kDa) occur in both the central and peripheral nervous system and are normally restricted to neurons. The 70 kDa NF-protein can self-assemble into a filamentous structure, whereas the 160 kDa and 200 kDa NF-proteins require the presence of the 70 kDa NF-protein to co-assemble. All three NF proteins can be detected by immunohistochemical methods at day 9 or 10 after gestation in the mouse embryo. Although IFPs of the neurofilament type are normally restricted to neurons, there are reports on their expression in non-neuronal cells as well. For example, in heart conduction myocytes NF proteins are expressed together with desmin. In tumorpathology ganglioneuroblastomas and some of the other neuroblastomas are strongly positive with the neurofilament antisera. Also, some neuro-endocrine malignancies may show NF positivity. In cell cultures of neural tissues the neurofilament antibodies can monitor in vitro differentiation.
ImmunogenRNF405 is a mouse monoclonal IgG2a antibody derived by fusion of SP2/0-Ag14 mouse myeloma cells with spleen cells from a mouse immunized with a neurofilament preparation of calf brain tissue.
Other NamesNF-H|NF200|Nfh|mKIAA0845|NFH|NEFH
Gene, Accession #Gene ID: 380684,24587,4744,100156492
Catalog #ABIN335259
Price
Order / More InfoNeurofilament, Heavy Polypeptide (NEFH) Antibody from ANTIBODIES-ONLINE GmbH
Product Specific Referencesn/a
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