产品名称 Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (aa 216-434) Antibody from ANTIBODIES-ONLINE GmbH
产品货号 ABIN94466
产品价格 现货询价,电话:010-67529703
产品规格 0.1 mg
产品品牌 ANTIBODIES-ONLINE GmbH
产品概述
产品详情
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Antigenic SpecificityLymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (aa 216-434)
CloneSLP-76-03
Host SpeciesMouse
Reactive Specieshuman, porcine, mouse
IsotypeIgG2b
FormatProtein G purified
Size0.1 mg
Concentrationn/a
ApplicationsImmunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Western Blotting (WB)
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DescriptionSLP76 (SH2 domain-containing leukocyte protein of 76 kDa) is a cytosolic adaptor protein which translocates to the plasma mambrane and is involved in multiple signaling pathways in T cells, mast cells, neutrophils and platelets, B cells express its analog SLP65/BLNK (B cell linker protein). SLP76 is phosphorylated by Syk-family and Tec-family tyrosine kinases and couples them to the phosphorylation and activation of PLC-gamma. Via Gads or Grb2, SLP76 also associates with LAT adaptor by involvement of SLP76 proline-rich region. The SH2 domain of SLP76 has been identified as the region involved in binding the serine/threonine kinase HPK1. HPK1 may act as both a positive and a negative regulator by promoting the Jnk-mitogen activated protein kinase (MAPK) pathway and inhibiting the pathway leading to AP-1 activation.
ImmunogenBacterially expressed fusion protein representing amino acids 216-434 of human SLP76 with histidine tag
Other NamesAI323664|BB161688|SLP-76|SLP76|twm|Slp76
Gene, Accession #Gene ID: 3937,100511843,16822
Catalog #ABIN94466
Price
Order / More InfoLymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (aa 216-434) Antibody from ANTIBODIES-ONLINE GmbH
Product Specific ReferencesPubMed: 16479002, 17148460, 16493428, 10377180
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