产品名称 IL3R α/ CD123 Antibody from DENDRITICS SAS
产品货号 DDX0301
产品价格 现货询价,电话:010-67529703
产品规格 100µg/50µg
产品品牌 DENDRITICS SAS
产品概述
产品详情
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Antigenic SpecificityIL3R α/ CD123
Clone106C2.02
Host SpeciesMouse
Reactive Specieshuman, swine
IsotypeIgG1
Formatpurified
Size100µg/50µg
Concentrationn/a
ApplicationsFACS surface, IF, IHC
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DescriptionIL-3 exerts its biologic activity (eg survival and proliferation of multipotent hematopoietic cells, development of pDCs) through its interaction with a cell surface receptor that consists of two subunits. The α subunit (CD123) specifically binds IL-3, whereas the ??subunit is required for signaling and is common to the GMCSF-R and IL-5-R. Interplay of α and ??chains leads to the formation of a high-affinity receptor complex able to transduce proliferative, apoptotic and differentiative signals. Plasmacytoid DCs express IL3-R and differentiate into functional DCs with IL-3. The leukemic pDC counterpart also expresses high levels of IL3-Rα. Upon IL-3 treatment in vitro, leukemic cells become inducers of T-cell proliferation, as reported for normal pDCs.The role of IL3-R in oncogenesis has been explored in several animal models. Overexpression of the IL3-R ? chain may represent one of the mechanisms contributing to the development of a highly malignant leukemic phenotype. Treilleux I et al., 2004, Clinical Cancer Research, 10: 7466-7474,
Immunogenn/a
Other Namesinterleukin
Gene, Accession #n/a
Catalog #DDX0301
Price
Order / More InfoIL3R α/ CD123 Antibody from DENDRITICS SAS
Product Specific Referencesn/a
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