| 产品详情 |
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| Antigenic Specificity | APE1 |
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| Clone | 13B 8E5C2 |
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| Host Species | Mouse |
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| Reactive Species | canine, human, mouse, nonhuman primate, rat |
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| Isotype | IgG2a |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | ChIP assay: 1.5 µg/10^6 cells, Flow Cytometry: 2-5 µg/mL, Immunocytochemistry: 1:50-1:500, Immunofluorescence: 1:50-1:500, Immunohistochemistry (Frozen): 1/5000, Immunohistochemistry (Paraffin): 1:50-1:1000, Immunoprecipitation: 5 µg, Western Blot: 1:1,000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | APE1 Monoclonal Antibody (13B 8E5C2). Mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is a multifunctional, bipartite enzyme that plays an important role in numerous, cellular functions. APE is responsible for repairing abasic sites in DNA and in regulating the redox state of other proteins that play roles in oxidative signaling, transcription factor regulation (Fos, Jun, NF-kB, Myb, HIF-1 alpha, CREB, Pax), cell cycle control (p53), and apoptosis. The most common form of DNA damage is the creation of abasic sites which are brought about through spontaneous loss or oxidative DNA damage, through chemically initiated hydrolysis (chemotherapy), ionizing radiation, UV irradiation, oxidizing agents, and removal of modified bases by DNA |
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| Immunogen | n/a |
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| Other Names | Apurinic/Apyrimidinic Endonuclease |
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| Gene, Accession # | Entrez: 11792, 328, 482558, 79116; Uniprot: P27695, P28352, P43138 |
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| Catalog # | MA1-440 |
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| Price | |
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| Order / More Info | APE1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 14581338 |
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| 产品资料 |
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