| 产品详情 |
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| Antigenic Specificity | Mus81 |
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| Clone | MTA30 2G10/3 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2a |
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| Format | Protein A purified |
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| Size | 50ul |
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| Concentration | 1mg/ml |
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| Applications | WB, IP, ICC/IF, Flow Cyt |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Mouse Anti-Mus81 [MTA30 2G10/3]. |
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| Immunogen | Mus81 protein |
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| Other Names | Crossover junction endonuclease MUS81, FLJ21012, FLJ44872, Mus 81; MUS81, MUS81 Endonuclease Homolog, MUS81_HUMAN |
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| Gene, Accession # | n/a |
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| Catalog # | IQ285 |
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| Price | |
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| Order / More Info | Mus81 Antibody from IMMUQUEST LTD. |
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| Product Specific References | Inagaki H et al. Two sequential cleavage reactions on cruciform DNA structures cause palindrome-mediated chromosomal translocations.Nat Commun. 2013;4:1592. doi: 10.1038/ncomms2595.WB ; Human PMID: 23481400 Murfuni I et al. Perturbed replication induced genome wide or at common fragile sites is differently managed in the absence of WRN. Carcinogenesis 33:1655-63 (2012) PUBMED Duquette ML et al. CtIP is required to initiate replication-dependent interstrand crosslink repair. PLoS Genet 8:e1003050 (2012). WB, ICC/IF ; Human PUBMED Stoepker C et al. SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype. Nat Genet 43:138-41 (2011). IP WB ; Human PMID: 21240277 Dominguez-Kelly R et al. Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease. J Cell Biol 194:567-79 (2011) PUBMED Regairaz M et al. Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I-DNA complexes. J Cell Biol 195:739-49 (2011) PUBMED Rass U et al. Mechanism of Holliday junction resolution by the human GEN1 protein. Genes Dev 24:1559-69 (2010). WB ; Human PUBMED Munoz IM et al. Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair.Mol Cell. 2009 Jul 10;35(1):116-27. doi: 10.1016/j.molcel.2009.06.020.WB ; Human PMID: 19595721 Zeng S et al. Telomere recombination requires the MUS81 endonuclease. Nat Cell Biol 11:616-23 (2009) PUBMED Svendsen JM et al. Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Cell 138:63-77 (2009). WB ; Human PUBMED Nomura Y et al. Human Mus81 and FANCB independently contribute to repair of DNA damage during replication.Genes Cells. 2007 Oct;12(10):1111-22.ICC/IF WB ; Human PMID: 17903171 Liu C et al. Increased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancer.Lung Cancer. 2007 Mar;55(3):303-11. Epub 2006 Nov 21.WB ; Human PMID: 17118488 Human Mus81 and FANCB independently contribute to repair of DNA damage during replication. Yuji Nomura et al ( Genes to Cells,October 2007)PUBMED Taylor ER & McGowan CH Cleavage mechanism of human Mus81-Eme1 acting on Holliday-junction structures. Proc Natl Acad Sci U S A 105:3757-62 (2008). IP ; Human PUBMED Franchitto A et al. Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway. J Cell Biol 183:241-52 (2008). WB ; Human PUBMED |
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