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| Product Name | TLR3/MDA5 agonist (POLY[I:C]) |
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| Description | TLR's have a central role in innate immunity and are also required for the development of an adaptive immune response. TLRs are expressed by various cells of the immune system, such as macrophages and dendritic cells. TLRs are class I receptors, with a single α-helix that spans the cell membrane. They recognize and respond to molecules derived from bacterial, viral and fungal pathogens, such as lipopolysaccharide (LPS) from the outer membrane of Gram negative bacteria, peptidoglycan fragments from bacterial cell walls and single-stranded and double-stranded RNA from viruses. Some forms of RNA and DNA from pathogens exhibit immutable features that distinguish them from nucleic acids of higher organisms. For example, dsRNA, is a common intermediate of viral replication and a potent indicator of infection. Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA and its synthetic analog polyriboinosinic:polyribocytidylic acid (poly[I:C]). TLR3 is normally located in acidic endosomes where its luminal ectodomain (ECD) encounters dsRNA and induces type I interferon (IFN), inflammatory cytokine/chemokine production and dendritic cell (DC) maturation via the adaptor protein TICAM-1 (also called TRIF). Based on the different subcellular localization of cytosolic RNA receptors and TLR3, these receptors seem to play distinct roles in anti-viral immune responses. |
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| Size | 5 mg |
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| Concentration | 5 mg lyophilized TLR3/MDA5 agonist. The endotoxin level of the product is <0.002 EU/µg. |
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| Applications | functional studies |
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| Other Names | Polyinosinic-polycytidylic acid, potassium salt (poly[I:C]) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | HC4067 |
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| Order / More Info | TLR3/MDA5 agonist (POLY[I:C]) from HYCULT BIOTECH |
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| Product Specific References | n/a |
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