产品名称 MPO, Human Antibody from HYCULT BIOTECH
产品货号 HM2288
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 HYCULT BIOTECH
产品概述
产品详情
Edit&nbsp
Antigenic SpecificityMPO, Human
CloneB7
Host SpeciesMouse
Reactive Specieshuman, human, rat
IsotypeIgG1
Formatunconjugated
Size100 µg
Concentration100 µg/ml
Applicationsfrozen sections, FC, immunoassay, WB
Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
DescriptionThe monoclonal antibody B7 recognizes human myeloperoxidase (MPO), an ~135 glycoprotein expressed in all cells of the myeloid linage. MPO functions as an α2β2 heteromultimer consisting of two heavy (α) and two light (β) chains of 55 and 15 kDa respectively. MPO is abundantly present in azurophilic granules of polymorphonuclear neutrophils (PMNs). It is an important enzyme used during phagocytic lysis of engulfed foreign particles which takes part in the defense of the organism through production of hypochlorous acid (HOCl), a potent oxidant. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Upon activation of neutrophils, MPO can be rapidly released and as such useful in body fluids as marker for inflammatory status. Involvement of MPO has been described in numerous diseases such as atherosclerosis, lung cancer, Alzheimer's disease, inflammatory bowel disease and multiple sclerosis. Autoimmune antibodies to MPO (so called ANCA) are involved in Wegener's disease. Since the discovery of MPO deficiency, initially regarded as rare and restricted to patients suffering from severe infections, MPO has attracted more clinical attention.
ImmunogenMouse MPO
Other NamesMyeloperoxidase
Gene, Accession #n/a
Catalog #HM2288
Price
Order / More InfoMPO, Human Antibody from HYCULT BIOTECH
Product Specific Referencesn/a
产品资料