| 产品详情 |
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| Antigenic Specificity | Ficolin-1, Human |
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| Clone | 7G1 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | unconjugated |
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| Size | 100 µg |
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| Concentration | 100 µg/ml |
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| Applications | FC, immunoassay, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The monoclonal antibody 7G1 recognizes human M-ficolin, also known as ficolin-1. Ficolins are a family of pattern recognition molecules containing both a collagen-like domain and a fibrinogen-like domain that are capable of activating the complement system, through association with MASPs, on the surface of microorganisms. In human, three Ficolins are known: M-Ficolin, L- Ficolin (Ficolin-2), and H-Ficolin (Ficolin-3). M-Ficolin, is mainly expressed by- monocytes, granulocytes and- lung cells and is present locally in areas of inflammation. However, it was recently also found in serum suggesting that M-Ficolin also has a role in systemic immunity like L- and H-Ficolin. Functional analysis of M-Ficolin has demonstrated that it’s ligand is sialic acid present on bacteria since binding was abolished by prior treatment of the bacteria with sialidase. Furthermore, it was shown that M-ficolin facilitates the uptake of E. coli- by a leukemic monocyte lymphoma cell line, suggesting that it functions as a phagocytic receptor on the surface of circulating monocytes. Low cord blood concentration of M-ficolin has been- associated with higher necrotizing enterocolitis-associated fatality and two identified SNPs in the M-ficolin gene are associated with the development of rheumatoid arthritis. The monoclonal antibody 7G1 is suitable for use in immunoassays and western blotting. - |
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| Immunogen | Full length recombinant M-Ficolin- |
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| Other Names | Ficolin-1, ficolin/P35-related |
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| Gene, Accession # | n/a |
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| Catalog # | HM2196 |
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| Price | |
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| Order / More Info | Ficolin-1, Human Antibody from HYCULT BIOTECH |
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| Product Specific References | n/a |
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