产品名称 Complement factor D, Human Antibody from HYCULT BIOTECH
产品货号 HM2258
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 HYCULT BIOTECH
产品概述
产品详情
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Antigenic SpecificityComplement factor D, Human
CloneD1/4
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG2a
Formatunconjugated
Size100 µg
Concentration100 µg/ml
Applicationsimmunoassay
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DescriptionThe monoclonal antibody D10/4 recognizes human complement factor D. Factor D, a 27 kDa serine protease of the alternative complement pathway, is synthesized as a precursor single-chain molecule. The alternative complement pathway represents an important humoral component of natural defense against microbial attack. The participation of the alternative complement pathway has been implicated in the pathogenesis of a wide variety of human diseases. Factor D is unique among serine proteases in that it requires neither enzymatic cleavage for expression of proteolytic activity nor activation by a serpin for its control. Factor D is highly specific and cleaves factor B bound to C3b, generating the C3bBb enzyme. Factor D is the rate-limiting C3 convertase enzyme of the alternative pathway. It has both the lowest plasma concentration and the lowest molecular weight of all complement components. Normal values in human EDTA plasma and urine are 1.05 (± 0.27) and 0.62 (± 0.33) µg/ml, respectively. In normal human subjects, factor D is rapidly eliminated via the kidney. Compared to controls, plasma and urine levels of factor D in patients with renal failure are elevated. Elevated plasma levels return to normal levels within seven days after successful renal transplantation to prevent overstimulation of the complement pathway. Human adipsin, a protein that is expressed at high levels in adipose tissue, is identical to factor D and also displays the same enzymatic activity as factor D. This suggests that factor D plays a role in fatty tissue distinct from its role as a complement protein.
ImmunogenSerum purified human factor D
Other NamesC3 convertase activator, Properdin factor D, Adipsin
Gene, Accession #n/a
Catalog #HM2258
Price
Order / More InfoComplement factor D, Human Antibody from HYCULT BIOTECH
Product Specific Referencesn/a
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