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| Product Name | Alpha-defensin 6, Human, Peptide |
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| Description | Defensins are small cysteine-rich cationic peptides containing three or four disulfide bridges. They are divided into families on the basis of the spatial distribution of their cysteine residues. Three families, the α-, β- and θ-defensins, can be distinguished in mammals. α- and β-defensins are characterized by antiparallel β-sheet structures stabilized by three disulfide bonds. The θ-defensins are found in rhesus monkey and some other non-human primates but not in human, chimpanzee and gorilla. They consist of two nine amino acid peptides derived from different precursor proteins joined by head-to-tail cyclization. Defensins protect human barriers from commensal and pathogenic microorganisms. Human α-defensin 6 (HD-6 with sequence AFTCHCRRSCYSTEYSYGTCTVMGINHRFCCL) is produced exclusively by small intestinal paneth cells. It is an antimicrobial peptide acting via 2 distinct antimicrobial mechanisms: HD-6 kills specific microbes depending on the local reducing environmental conditions, whereas known microbial trapping by extracellular net structures is independent of the reducing milieu. |
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| Size | 50 µg |
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| Concentration | Lyophilized product in PBS, containing 50 µg HD-6. |
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| Applications | functional studies, WB |
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| Other Names | HD-6, DEF6, Alpha defensin 6, HD6 |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | HC2137 |
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| Order / More Info | Alpha-defensin 6, Human, Peptide from HYCULT BIOTECH |
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| Product Specific References | n/a |
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