| 产品详情 |
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| Antigenic Specificity | ACER1 (aa 141-190) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | unconjugated |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit Anti-Human ACER1 polyclonal antibody for WB. Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum;corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can;trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and;sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers;regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at;the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is;highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine;(Houben et al., 2006 (PubMed 16477081); Sun et al., 2008 (PubMed 17713573)). |
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| Immunogen | Synthetic peptide |
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| Other Names | n/a |
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| Gene, Accession # | Gene ID: 125981, UniProt: Q8TDN7 |
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| Catalog # | CABT-BL179 |
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| Price | |
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| Order / More Info | ACER1 (aa 141-190) Antibody from CREATIVE DIAGNOSTICS |
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| Product Specific References | n/a |
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| 产品资料 |
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