| 产品详情 |
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| Product Name | Triptolide |
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| Description | Inhibits DNA-dependent ATPase activity of XBP and induces inhibition of RNA polymerase II (RNAPII)-mediated transcription (IC50 = 200 nM). Selective for RNAPII over RNAPI and RNAPIII. Blocks RNA synthesis in HeLa cells (IC50 = 62 nM); exhibits potent antiproliferative activity in 60 cancer cell lines (average IC50 = 12 nM) and induces apoptosis by blocking TNF-α-mediated c-IAP1 and c-IAP2 induction. Also displays immunosuppressive and anti-inflammatory activity. Purity 98%. MW (observed): 360.4 |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one |
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| Gene, Accession, CAS # | CAS: 38748-32-2 |
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| Catalog # | 3253/1 |
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| Price | |
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| Order / More Info | Triptolide from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 22898817, 24516381, 25558795 |
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| 产品资料 |
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