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| Product Name | SC-58125 |
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| Description | SC-58125 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK 966 (rofecoxib), DUP-697, and celecoxib. SC-58125 is a potent and time-dependent inhibitor of COX-2.{1299} When tested on the isolated recombinant enzymes, SC-58125 is at least 150 times more potent in the inhibition of COX-2 as COX-1.{3464} In cultured HUVEC cells, SC-58125 inhibits COX-2 with an IC50 value of 70 nM.{5498} It also inhibits the growth of the COX-2 expressing cell line HCA-7 in nude mice at 5-10 mg/kg when given intraperitoneally.{6465} |
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| Size | 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | selective inhibitors inhibits COX-2 cox2 pghs2 pghs-2 prostaglandin synthases synthase-2 sc58125 cyclooxygenases diaryl heterocycles time-dependent |
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| Gene, Accession, CAS # | CAS: 162054-19-5 |
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| Catalog # | 70655-25 |
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| Order / More Info | SC-58125 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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