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| Antigenic Specificity | MARCO, Human |
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| Clone | PLK-1 |
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| Host Species | Mouse |
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| Reactive Species | human, bovine |
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| Isotype | IgG3 |
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| Format | unconjugated |
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| Size | 100 µg |
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| Concentration | 100 µg/ml |
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| Applications | frozen sections, FC, functional studies, IF, IP, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The monoclonal antibody PLK-1 recognizes the macrophage receptor with collagenous structure (MARCO). The scavenger receptors (SRs) expressed by macrophages are thought to play an important role in the immune response against bacteria by mediating ligand binding and phagocytosis. SRs can be divided into three different classes based upon their structural properties, which are termed SR-A, SR-B and SR-C. SRs-A are homotrimeric glycoproteins composed of 77 kDa monomers subdivided into 3 types. The molecular structure of MARCO resembles that of SR-A type I, containing a triple-helical collagenous domain and a scavenger receptor cysteine-rich (SRCR) domain at the C terminus. MARCO is only expressed in some subpopulations of macrophages, although its expression can be strongly upregulated during infection or LPS treatment. Furthermore, MARCO is, like sinusoidal endothelial cell markers DC-SIGNR, LYVE-1 and stabilin-2, expressed by sinusoidal endothelial cells in lymph node. MARCO expressed by alveolar macrophages seems to play an important role in response to inhaled particles and airborne pathogens. The monoclonal antibody PLK-1 binds specifically to MARCO, and has been shown to partially block ligand binding. |
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| Immunogen | Human alveolar macrophages (recognizes domain V between residues 420 and 431) |
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| Other Names | SCARA2, scavenger receptor class A member 2, macrophage receptor with collagenous structure |
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| Gene, Accession # | n/a |
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| Catalog # | HM2208 |
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| Order / More Info | MARCO, Human Antibody from HYCULT BIOTECH |
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| Product Specific References | n/a |
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