| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | Lipid A |
|---|
| Clone | 26-5 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | n/a |
|---|
| Isotype | IgG2b |
|---|
| Format | unconjugated |
|---|
| Size | 100 µg |
|---|
| Concentration | 100 µg/ml |
|---|
| Applications | immunoassay |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | The monoclonal antibody 26-5 recognizes lipid A. The lipid A domain of lipopolysaccharide (LPS) is a unique, glucosamine-based phospholipid that makes up the outer monolayer of the outer membrane of most gram-negative bacteria. Lipid A is responsible for the endotoxic activities of LPS, and a heteropolysaccharide. The heteropolysaccharide generally consists of an oligosaccharide termed the core region. This core region is in some bacterial families composed of repeating oligosaccharide units, the so-called O chain. The lipid A moiety of LPS is detected by the TLR4/MD2 receptor of the mammalian innate immune system. Picomolar levels of lipid A induce macrophages to synthesize potent mediators of inflammation, such as TNF-α and IL-1β. Furthermore, lipid A activates the production of costimulatory molecules required for adaptive immunity and stimulates tissue factor production in mononuclear and endothelial cells. All these events are desirable for clearing local infections. |
|---|
| Immunogen | n/a |
|---|
| Other Names | n/a |
|---|
| Gene, Accession # | n/a |
|---|
| Catalog # | HM6009 |
|---|
| Price | |
|---|
| Order / More Info | Lipid A Antibody from HYCULT BIOTECH |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|