产品名称 LBP, Mouse Antibody from HYCULT BIOTECH
产品货号 HM1027
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 HYCULT BIOTECH
产品概述
产品详情
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Antigenic SpecificityLBP, Mouse
CloneRR433-8
Host SpeciesRat
Reactive Speciesmouse
IsotypeIgG2a
Formatunconjugated
Size100 µg
Concentration100 µg/ml
Applicationsfunctional studies, immunoassay, WB
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DescriptionThe monoclonal antibody RR433-8 reacts highly specific with mouse natural and recombinant LBP. The antibody is a type II antibody blocking the LPS binding to CD14. LPS binding protein (LBP) is an approximately 60 kDa acute phase protein that is produced by hepatocytes. This protein strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to an 100-1,000-fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. Next, LBP transfers LPS into High Density Lipoprotein (HDL), which effectively neutralizes its biological potency. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria.
Immunogenn/a
Other Namesn/a
Gene, Accession #n/a
Catalog #HM1027
Price
Order / More InfoLBP, Mouse Antibody from HYCULT BIOTECH
Product Specific Referencesn/a
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