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| Antigenic Specificity | TNF-alpha, Human |
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| Clone | 52B83 |
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| Host Species | Mouse |
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| Reactive Species | human, guinea pig, mouse, rhesus monkey |
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| Isotype | IgG1 |
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| Format | unconjugated |
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| Size | 100 µg |
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| Concentration | 100 µg/ml |
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| Applications | frozen sections, FC, immunoassay, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The monoclonal antibody 52B83 reacts with tumor necrosis factor alpha (TNF-alpha). TNF-alpha is a homotrimeric 17 kDa protein, that interacts with either one of the two types of TNF-receptors, termed I and II, leading to receptor cross-linking and signal transduction. The receptors differ strongly in their intra-cellular signaling pathways. TNF-alpha was originally described as a highly cytotoxic cytokine for tumor cells, it causes tumor necrosis in vivo and shows cytolytic activity against tumor cells in vitro. Furthermore,- TNF-alpha is found to be a central mediator in many inflammatory and immunological processes. It can be induced by various products of micro-organisms and by various cytokines leading to expression of a wide variety of- cytokines. The pro-inflammatory properties of- TNF-alpha play a central role in several auto-immune diseases such as rheumatoid arthritis and inhibition by neutralizing molecules have been shown to be beneficial in patients. |
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| Immunogen | n/a |
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| Other Names | Tumor Necrosis Factor-alpha, TNF, TNF-SF2, cachectin |
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| Gene, Accession # | n/a |
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| Catalog # | HM2010 |
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| Price | |
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| Order / More Info | TNF-alpha, Human Antibody from HYCULT BIOTECH |
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| Product Specific References | n/a |
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