| 产品详情 |
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| Antigenic Specificity | CD46, Human |
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| Clone | M177 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | unconjugated |
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| Size | 0.5 mg |
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| Concentration | n/a |
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| Applications | frozen sections, FC, functional studies, immunoassay, IP, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The monoclonal antibody M177 recognizes CD46, also designated membrane cofactor protein (MCP). CD46 is a 45-70 kDa protein with genetic and tissue-specific heterogeneity.- It is expressed on every cell and tissue, with the exception of erythrocytes. CD46 serves to inhibit complement activation on host tissue. It performs this function by serving as a cofactor which binds to C3b and C4b. This binding is permitted by factor I, a serine protease of plasma, to degrade C3b and C4b and serves to protect the host cell against autologous attack. It also serves as a receptor for measles virus. Four isoforms of CD46 predominate and arise by alternative splicing of a single CD46 gene. CD46 cDNA encodes a signal sequence followed by four complement control protein domains (also called short consensus repeats (SCR)). The monoclonal antibody M177 reacts with the SCR2 domain. |
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| Immunogen | Purified MCP |
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| Other Names | Membrane cofactor protein, TLX, trophoblast leucocyte common antigen. |
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| Gene, Accession # | CD46 |
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| Catalog # | HM2103-IA |
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| Price | |
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| Order / More Info | CD46, Human Antibody from HYCULT BIOTECH |
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| Product Specific References | n/a |
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