产品名称 CD180, Human Antibody from HYCULT BIOTECH
产品货号 HM2084
产品价格 现货询价,电话:010-67529703
产品规格 50 µg
产品品牌 HYCULT BIOTECH
产品概述
产品详情
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Antigenic SpecificityCD180, Human
CloneMHR73
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG1
Formatbiotin conjugate
Size50 µg
Concentration100 µg/ml
Applicationsfrozen sections, FC
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DescriptionThe monoclonal antibody MHR73 reacts with human RP105 (CD180). RP105 is a type 1 transmembrane protein of 105 kDa with extracellular leucine-rich repeats (LLRs) and a short cytoplasmic tail. RP105, assigned as CD180, is similar to Drosophila Toll in the extracellular LLRs. RP105 expression is largely restricted to immune cells including CD19+ B cells and macrophages. Histological studies showed that RP105 is expressed mainly on mature B cells in mantle zones. Antibody-mediated (MHR73) cross-linking of RP105 induces resistance against irradiation-induced apoptosis, B-cell proliferation, and up-regulation of a costimulatory molecule CD80, revealing RP105 as a potent regulator of B-cell activation. In this context it is important to note that RP105 is associated with MD1, and that it mediates B-cell surface expression and LPS recognition and signalling in cooperation with TLR4. MD-1 seems to be requisite for efficient expression of RP105.
Immunogenn/a
Other Namesn/a
Gene, Accession #n/a
Catalog #HM2084
Price
Order / More InfoCD180, Human Antibody from HYCULT BIOTECH
Product Specific Referencesn/a
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