产品名称 CD166, Human Antibody from HYCULT BIOTECH
产品货号 HM2002
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 HYCULT BIOTECH
产品概述
产品详情
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Antigenic SpecificityCD166, Human
CloneAZN-L5
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG2a
Formatunconjugated
Size100 µg
Concentration100 µg/ml
Applicationsfrozen sections, FC, functional studies, IF, IP, paraffin sections, WB
Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
DescriptionThe monoclonal antibody AZN-L50 recognizes activated leukocyte cell adhesion molecule (ALCAM), a member of the immunoglobulin superfamily and has a characteristic VVC2C2C2 domain structure. ALCAM is a type I transmembrane protein of 100 kDa with five extracellular immunoglobulin-like domains and a short cytoplasmic tail. ALCAM mediates homotypic ALCAM-ALCAM interactions and heterotypic interactions with the T-cell antigen CD6. Homotypic interactions are involved in the development and maintenance of tissue architecture and tumor progression. Heterotypic interactions initiate and stabilize T-cell-dendritic interactions affecting T-cell activation. ALCAM is secreted as a NH2-terminal fragment of 30 kD. Soluble ALCAM (sALCAM) induces divergent biological signals and responses. ALCAM shows a characteristic, temporal and spatial distribution in development of a wide variety of tissues and cells in health and disease. ALCAM is expressed on a wide variety of cells, within the leukocyte population its expression is particularly high on dentritic cells. ALCAM is involved in various physiological processes including hematopoieses, thymus development, the immune response, neurite extension, neural cell migration, embryogenesis, neurogenesis, angiogenesis, osteogenesis and is a marker for pluripotent mesenchymal stem cells. The monoclonal antibody AZN-L50 completely blocks homophilic ALCAM-ALCAM interaction.
ImmunogenCD166 expressing K562 cells
Other NamesActivated leukocyte cell adhesion molecule, ALCAM, CD166.
Gene, Accession #n/a
Catalog #HM2002
Price
Order / More InfoCD166, Human Antibody from HYCULT BIOTECH
Product Specific Referencesn/a
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