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| Antigenic Specificity | Synaptotagmin 1 |
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| Clone | 41.1 |
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| Host Species | Mouse |
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| Reactive Species | human, rat, mouse, zebrafish |
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| Isotype | IgG2a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | IHC, Paraffin Sections (FFPE), Frozen Sections, Immunoprecipitation, ELISA |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Ca2+ sensor widely expressed in teh nervous system. Synaptotagmin 1 is an integral membrane glycoprotein of neuronal synaptic vesicles and secretory granules of neuroendocrine cells that is widely (but not ubiquitously) expressed in the central and peripheral nervous system. Ca2+-binding to synaptotagmin triggers exocytosis of synaptic vesicles, thus linking Ca2+-influx during depolarization to neurotransmitter release. Synaptotagmin is expressed in mast cells of normal human tissues and potentially involved in histamine release in allergic and asthmatic reactions. |
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| Immunogen | Recombinant protein of rat synaptotagmin 1 (aa 80 - 421) containing the C-terminal part. |
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| Other Names | P65, SVP65, SYT, synaptotagmin 1, synaptotagmin-1, sytI |
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| Gene, Accession # | SYT1, 6857 |
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| Catalog # | SySy105011 |
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| Price | |
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| Order / More Info | Synaptotagmin 1 Antibody from DIANOVA GmbH |
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| Product Specific References | Synaptic pathology, altered gene expression, and degeneration in photoreceptors impacted by drusen. Johnson PT, Brown MN, Pulliam BC, Anderson DH & Johnson LV. Investigative Ophtalmology and Visual Science 46: 4788-95, 2005. / Brain synaptic junctional proteins at the acrosome of rat testicular germ cells. Redecker P, Kreutz MR, Bockmann J, Gundelfinger ED & Boeckers TM. Journal of Histochemistry and Cytochemistry 51: 809-19, 2003. / Changes in retinal synaptic proteins in the transgenic model expressing a mutant HRG4 (UNC119). Kubota S, Kobayashi A, Mori N, Higashide T, McLaren MJ & Inana G. Investigative Ophtalmology and Visual Science 43: 308-13, 2002. / Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of ribbon synapses. von Kriegstein K, Schmitz F, Link E & Sudhof T. European Journal of Neuroscience 11: 1335-48, 1999. |
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