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| Product Name | A 83-01 |
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| Description | Potent inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively). Blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. Only weakly inhibits ALK-1, -2, -3, -6 and MAPK activity. More potent than SB 431542 (Cat.No. 1614). Inhibits differentiation of rat induced pluripotent stem cells (riPSCs) and increases clonal expansion efficiency. Helps maintain homogeneity and long-term in vitro self-renewal of human iPSCs. Purity 98%. MW (observed): 421.52 |
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| Size | 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide |
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| Gene, Accession, CAS # | CAS: 909910-43-6 |
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| Catalog # | 2939/50 |
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| Order / More Info | A 83-01 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 20660726, 21305472, 22927969, 23324343, 23666117, 23728301, 23917481, 23935837, 24204693, 24637302, 25064463, 25437872, 25533785, 25557080, 25610469, 25634246, 25693565, 25740845, 25822089, 25870291, 26332312, 26354680, 26365514, 26455412, 26460009, 26677983, 26797458, 27133794, 27320041, 27819344, 28165492, 28669603, 29168693, 29358044 |
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