| 产品详情 |
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| Product Name | CpG-DNA, Mouse |
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| Description | Bacterial DNA is known to induce acute inflammatory responses. Bacterial DNA acts as a pathogen-associated molecular pattern by virtue of a 20-fold greater frequency of unmethylated CG dinucleotides found in microbial DNA versus vertebrate DNA. Cellular activation by deoxy-cytidylate-phosphate-deoxy-guanylate (CpG)-DNA occurs via the Toll/IL-1R signal pathway. TLR9 appears to be a major component of the CpG-DNA receptor, acting by direct binding to CpG-DNA. The synthetic oligodeoxynucleotides (ODN) contain the proper CpG-DNA motif mimicing the immunostimulatory effects of bacterial DNA. The human optimal CpG motif GTCGTT differs from the optimal mouse CpG motif GACGTT. Non CpG-DNA has been shown to compete with CpG-DNA in in vitro stimulation experiments. This mouse CpG is a 20-mer ODN has the following sequence: 5'-tccatgacgttcctgatgct-3'. Regular letters represent phosphorothiorate linkage. |
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| Size | 200 nmol |
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| Concentration | Approximately 200 nmol lyophilized, purified 20-mer CpG ODN. |
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| Applications | functional studies |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | HC4033 |
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| Price | |
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| Order / More Info | CpG-DNA, Mouse from HYCULT BIOTECH |
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| Product Specific References | n/a |
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