产品名称 Abeta-pE11 Antibody from DIANOVA GmbH
产品货号 SySy218811
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 DIANOVA GmbH
产品概述
产品详情
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Antigenic SpecificityAbeta-pE11
Clone173D8
Host SpeciesMouse
Reactive Specieshuman, rat, mouse
IsotypeIgG2b
Formatpurified
Size100 µg
Concentrationn/a
ApplicationsIHC, Paraffin Sections (FFPE), Frozen Sections, Western Blot, Immunocytochemistry, ELISA
Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
DescriptionAmyloid deposits, also called plaques, of Alzheimer's patients consist of several protein components like the amyloid beta-peptides (Abeta, Aβ) 1-40/42 and additional C- and N-terminally truncated and modified fragments. Very abundant are the isoaspartate (isoAsp)-Abeta and pyroglutamyl (pGlu)-Abeta peptides. The latter are formed by cyclization of the N-terminal glutamate at position 3 or 11 catalyzed by glutaminyl cyclase (QC) resulting in very amyloidogenic and neurotxic variants of Abeta; Abeta-pE3 and Abeta pE11. In contrast to extracellular plaques that do not perfectly correlate with Alzheimer?s disease intraneuronal Abeta accumulation and vascular Abeta deposits have gained more and more evidence to be among the crucial factors responsible for progressive neuron loss.
ImmunogenSynthetic peptide pyr-EVHHQK-C coupled to key-hole limpet hemocyanin via an added C-terminal cysteine residue.
Other NamespE-Abeta; pGlu-Abeta; Abeta(11(pE)-40; 42); pyro-glu-Abeta
Gene, Accession #APP, 351
Catalog #SySy218811
Price
Order / More InfoAbeta-pE11 Antibody from DIANOVA GmbH
Product Specific Referencesn/a
产品资料