产品名称 Abeta-pE3 Antibody from DIANOVA GmbH
产品货号 SySy218011
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 DIANOVA GmbH
产品概述
产品详情
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Antigenic SpecificityAbeta-pE3
Clone2-48
Host SpeciesMouse
Reactive Specieshuman, rat, mouse
IsotypeIgG1
Formatpurified
Size100 µg
Concentrationn/a
ApplicationsIHC, Paraffin Sections (FFPE), Frozen Sections, Western Blot, Immunoprecipitation, Immunocytochemistry, ELISA
Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
DescriptionAmyloid deposits, also called plaques, of Alzheimer's patients consist of several protein components like the amyloid beta-peptides (Abeta, Aβ) 1-40/42 and additional C- and N-terminally truncated and modified fragments. Very abundant are the isoaspartate (isoAsp)-Abeta and pyroglutamyl (pGlu)-Abeta peptides. The latter are formed by cyclization of the N-terminal glutamate at position 3 or 11 catalyzed by glutaminyl cyclase (QC) resulting in very amyloidogenic and neurotoxic variants of Abeta; Abeta-pE3 and Abeta pE11. In contrast to extracellular plaques that do not perfectly correlate with Alzheimer?s disease intraneuronal Abeta accumulation and vascular Abeta deposits have gained more and more evidence to be among the crucial factors responsible for progressive neuron loss.
ImmunogenSynthetic peptide pyr-EFRHD coupled to key-hole limpet hemocyanin via an added C-terminal cysteine residue.
Other NamesAPP, amyloid beta (A4) precursor protein, AD1, Alzheimer disease, amyloid beta A4 protein, peptidase nexin II, preA4, protease nexin-II, peptidase nexin-II, beta-amyloid peptide, alzheimer disease amyloid protein, cerebral vascular amyloid peptide, AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, PN-II, CTFgamma
Gene, Accession #APP, 351
Catalog #SySy218011
Price
Order / More InfoAbeta-pE3 Antibody from DIANOVA GmbH
Product Specific ReferencesOligomeric Pyroglutamate Amyloid-β is Present in Microglia and a Subfraction of Vessels in Patients with Alzheimer's Disease: Implications for Immunotherapy. Wirths O, Hillmann A, Pradier L, Hartig W & Bayer TA. Journal of Alzheimer's Disease, Mar 12 [Epub ahead of print], 2013. / Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation. Alexandru A, Jagla W, Graubner S, Becker A, Bauscher C, Kohlmann S, Sedlmeier R, Raber KA, Cynis H, Ronicke R, Reymann KG, Petrasch-Parwez E, Hartlage-Rubsamen M, Waniek A, Rossner S, Schilling S, Osmand AP, Demuth HU & von Horsten S. Journal of Neuroscience 31: 12790-801, 2011. / Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms. Hartlage-Rubsamen M, Morawski M, Waniek A, Jager C, Zeitschel U, Koch B, Cynis H, Schilling S, Schliebs R, Demuth HU & Ro ner S. Acta Neuropathologica 121: 705-19, 2011. / Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Abeta aggregation in the 5XFAD mouse model of Alzheimer's disease. Jawhar S, Trawicka A, Jenneckens C, Bayer TA & Wirths O. Neurobiology of Aging, Jul 8 [Epub ahead of print] 2010. / Concomitant detection of beta-amyloid peptides with N-terminal truncation and different C-terminal endings in cortical plaques from cases with Alzheimer's disease, senile monkeys and triple transgenic mice. Hartig W, Goldhammer S, Bauer U, Wegner F, Wirths O, Bayer TA & Grosche J. Journal of Chemical Neuroanatomy 40: 82-92 Clone 2-48, 2010. / Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases. Wirths O, Bethge T, Marcello A, Harmeier A, Jawhar S, Lucassen PJ, Multhaup G, Brody DL, Esparza T, Ingelsson M, Kalimo H, Lannfelt L & Bayer TA. Journal of Neural Transmission 117: 85-96. Clone 2-48, 2010.
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