| 产品详情 |
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| Antigenic Specificity | CD23 |
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| Clone | 9P25 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | nd |
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| Format | purified |
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| Size | 100µg/50µg |
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| Concentration | n/a |
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| Applications | FACS, study of IgE binding to B cells |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD23, also known as Fc epsilon RII, or FcεRII, is the low affinity receptor for IgE, an antibody isotype involved in allergy and resistance to parasites and is important in regulation of IgE levels. Human rIL-4 is able to induce the expression of low-affinity receptors for IgE (Fc epsilon RL/CD23) on resting B lymphocytes, as determined by the binding of either the anti Fc epsilon RL/CD23-specific mAb 25 or IgE. Stimulation of B cells with insolubilized anti-IgM antibody increases the number of cells expressing Fc epsilon RL/CD23 upon culturing with IL-4 and enhances the level of Fc epsilon RL/CD23 expression on these cells. Fc epsilon RL/CD23 induction is specific for IL-4 since IL-1 alpha, IL-2, IFN-gamma, B cell-derived B cell growth factor (BCGF), and a low-molecular-weight BCGF were ineffective. IFN-gamma strongly inhibited the induction of Fc epsilon RL/CD23 by IL-4. CD23 is a 45 kDa transmembrane glycoprotein associated with MHC Class II antigen, which belongs to the C-type lectin family. Expression of CD23 by B lymphocytes is up-regulated following mitogen or antigen activation. Soluble forms of CD23 are generated by proteolytic cleavage of the membrane molecule. (Defrance T. et al., J Exp Med, 1987,165, 1459 ; Bonnefoy J-Y., et al., 1996, Eur.Respir.J., 9, 635-665). |
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| Immunogen | n/a |
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| Other Names | n/a |
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| Gene, Accession # | n/a |
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| Catalog # | DDX0600 |
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| Price | |
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| Order / More Info | CD23 Antibody from DENDRITICS SAS |
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| Product Specific References | n/a |
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