| 产品详情 |
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| Product Name | BMH-21 |
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| Description | An RNA polymerase I inhibitor; inhibits expression of the 47S rRNA transcript (IC50 = 60 nM), disrupts the structure of the nucleolus, and leads to removal of the RNA polymerase complex from rDNA by inducing dissociation and destruction of RPA194 through a proteasome-dependent mechanism; activates p53 in the nanomolar range; reduces viability of several cancer cell lines but not of non-cancerous cells (IC50s = 0.7, 1.9, ≥40, and 2.7 µM for A375, human diploid fibroblasts, primary human melanocytes, and HIMEC cells, respectively); inhibits tumor growth in melanoma and colon cancer mouse xenograft models when used at a dose of 25 mg/kg |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | BMH21 p 53 RPA-194 A-375 |
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| Gene, Accession, CAS # | CAS: 896705-16-1 |
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| Catalog # | 22282-10 |
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| Price | |
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| Order / More Info | BMH-21 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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