| 产品详情 |
| Edit |   |
|---|
| Product Name | G-5555 |
|---|
| Description | A PAK1 inhibitor (Ki =3.7 nM); selective for PAK1 over the majority of targets in a panel of 235 kinases but does inhibit PAK2, PAK3, KHS1, LCK, MST3, MST4, SIK2, and YSK1 by greater than 70% (IC50s = 9-52 nM); inhibits phosphorylation of MEK (IC50 = 69 nM in EBC1 cells); reduces phosphorylation of MEK in tumors from an H292 NSCLC mouse xenograft model (10, 20, and 30 mg/kg); inhibits hERG channels by less than 50% at a concentration of 10 µM |
|---|
| Size | 5 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | G5555 PAK-1 2 3 KHS-1 MST-3 4 SIK-2 YSK-1 H-292 p-21 EBC-1 |
|---|
| Gene, Accession, CAS # | CAS: 1648863-90-4 |
|---|
| Catalog # | 21469-5 |
|---|
| Price | |
|---|
| Order / More Info | G-5555 from CAYMAN CHEMICAL COMPANY |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|