| 产品详情 |
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| Antigenic Specificity | Caspase 1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 1 mL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:50 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Caspase 1 Polyclonal Antibody. Caspase-1/ICE (Interleukin-1Beta Converting Enzyme) is expressed as a proenzyme of 45kDa in many tissues. Upon stimulus, it gets activated by proteolytic cleavage. Active caspase-1 is a tetramer of two subunits p10 and p20 in 2; 2 proportion. Caspase-1 (cystein aspartic-specific protease 1) cleaves its substrates after an aspartate residue. It cleaves Interleukin Beta into its active form which further exerts its proinflammatory effects. Overexpression of caspase-1 can induce apoptosis in fibroblast, which can be inhibited by overexpression of Crm A, a protein from pox virus. |
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| Immunogen | n/a |
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| Other Names | ICE, IL1BC, P45, CASP1 nirs variant 1, IL-1 beta-converting enzyme, IL1B-convertase, caspase 1, apoptosis-related cysteine peptidase interleukin 1, beta, convertase, caspase-1, interleukin 1, beta, convertase, interleukin 1-B converting enzyme |
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| Gene, Accession # | Entrez: 834; Uniprot: P29466 |
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| Catalog # | PA1-37232 |
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| Price | |
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| Order / More Info | Caspase 1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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