| 产品详情 |
| Edit |   |
|---|
| Product Name | EPZ5676 |
|---|
| Description | A highly potent and selective inhibitor of DOT1L histone methyltransferase activity (Ki = 80 pM); inhibits the H3K79 methylation in various human leukemia cell lines (IC50s = 3-5 nM), decreasing MLL-fusion target gene expression and inhibiting proliferation; intravenous infusion of EPZ-5676 at a dose of 35 mg/kg can regress tumors in a rat xenograft model of MLL-rearranged leukemia |
|---|
| Size | 10 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 1380288-88-9 inhibitors DOT1L histones methyltransferases MLL-rearranged leukemias epigenetics inhibits inhibitions EPZ5676 EPZ 5676 DOT1L domains genes DNA damages repairs cells cycles regulations MLL drugs aminonucleosides expressions translocations intravenous infusions tumors regression rats xenografts EPZ-5676 potent selective H3K79 |
|---|
| Gene, Accession, CAS # | CAS: 1380288-87-8 |
|---|
| Catalog # | 16175-10 |
|---|
| Price | |
|---|
| Order / More Info | EPZ5676 from CAYMAN CHEMICAL COMPANY |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|