| 产品详情 |
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| Product Name | AZD 5363 |
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| Description | A pan-Akt inhibitor (Akt1, 2, and 3 IC50s = 3, 7, and 7 nM, respectively) that also inhibits P70S6K and PKA (IC50s = 6 and 7 nM, respectively) and shows >75% inhibition at 1 µM against ROCK-II, MKK1, MSK1, MSK2, PKCγ, PKGα, PKGβ, PRKX, RSK2, and RSK3; inhibits the proliferation of various tumor cell lines both in vitro and in vivo, demonstrating the greatest sensitivity towards breast cancer derived-cells or those with PIK3CA and/or PTEN mutations |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PKBα PKB.alpha. PKBalpha PKBa PKBβ PKB.beta. PKBbeta PKBb PKBγ PKB.gamma. PKBgamma PKBg PKBs Akts inhibitor Akt1 Akt2 Akt3 1 2 3 one two three P70S6K PKA ROCK2 MKK1 MSK1 MSK2 PKCγ PKC.gamma. PKCgamma PKCg PKCs PKGα PKG.alpha. PKGalpha PKGa PKGβ PKG.beta. PKGbeta PKGb PKGs PRKX RSK2 RSKS RSK3 cancers PIK3CA PTEN mutations antitumor tumors drugs resistances kinases pan-AKT pan inhibitors inhibitions inhibits pyrrolopyrimidine derived pyrrolopyrimidine-derived hematologic breast cancers intracellular signaling signals transduction AZD5363 AZD-5363 α .alpha. alpha a β .beta. beta b γ .gamma. gamma g |
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| Gene, Accession, CAS # | CAS: 1143532-39-1 |
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| Catalog # | 15406-10 |
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| Order / More Info | AZD 5363 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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