产品名称 Sortilin 1 (SORT1) (N-Term) Antibody from ANTIBODIES-ONLINE GmbH
产品货号 ABIN350871
产品价格 现货询价,电话:010-67529703
产品规格 100 µL
产品品牌 ANTIBODIES-ONLINE GmbH
产品概述
产品详情
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Antigenic SpecificitySortilin 1 (SORT1) (N-Term)
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
Formatserum
Size100 µL
Concentrationn/a
ApplicationsImmunohistochemistry (IHC),Western Blotting (WB)
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DescriptionFunction: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.Subunit: Interacts with the cytosolic adapter proteins GGA1 and GGA2. Interacts with numerous ligands including the receptor-associated protein LRPAP1/RAP and GM2A, LPL, PSAP and SLC2A4. Forms a complex with NGFR which binds specifically to the precursor form of NGFB (proNGFB). Interacts with the precursor form of BDNF (proBDNF).Subcellular location: Membrane, Single-pass type I membrane protein. Note: Localized to membranes of the endosomes, Golgi stack, lysosomes and nucleus. Localization to the plasma membrane in adipocytes is enhanced by insulin. Localized to the endoplasmic reticulum and the plasma membrane. Also found in SLC2A4/GLUT4 storage vesicles (GSVs) in adipocytes.Tissue specificity: Expressed at high levels in brain, spinal cord, heart, skeletal muscle, thyroid, placenta and testis. Expressed at lower levels in lymphoid organs, kidney, colon and liver. Also known as: Neurotensin receptor 3, NTR3, NT3, Glycoprotein 95, Gp95, 100 kDa NT receptor.
ImmunogenA synthetic peptide from the extracellular, N-terminal region of human Sortilin (Neurotensin receptor 3, NTR3, Sort1) conjugated to an immunogenic carrier protein was used as the immunogen.
Other NamesSORT1|19.m02079|gp95|ldlcq6|sortilin|Gp95|LDLCQ6|NT3|2900053A11Rik|AI852375|Ntr3|Ntsr3|Nt3|Nts3|sort1|zgc:85953
Gene, Accession #Gene ID: 6272
Catalog #ABIN350871
Price
Order / More InfoSortilin 1 (SORT1) (N-Term) Antibody from ANTIBODIES-ONLINE GmbH
Product Specific ReferencesPubMed: 16710414, 12209882, 12598608, 9756851, 10085125, 11331584, 11859376, 15930396, 18088087, 9013611
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