| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | Estrogen Receptor 1 (ESR1) |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | mouse, rat, human |
|---|
| Isotype | n/a |
|---|
| Format | affinity purified |
|---|
| Size | 200 µg |
|---|
| Concentration | n/a |
|---|
| Applications | Western Blotting (WB) |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Estrogen receptor alpha (ERalpha), a member of the steroid receptor superfamily, contains highly conserved DNA binding (DBD) and ligand binding domains (LBD). Through its estrogen-independent and estrogen-dependent activation domains (AF-1 and AF-2, respectively), ERalpha regulates transcription by recruiting coactivator proteins and interacting with general transcriptional machinery. Phosphorylation provides an important mechanism to regulate ERalpha activity. ERalpha is phosphorylated on multiple sites. Ser104, 106, 118 and 167 are located in the amino-terminal transcription activation function domain AF-1, and phosphorylation of these serines plays an important role in regulating ERalpha activity. Ser118 may be the substrate of the transcription regulatory kinase CDK7. Ser167 may be phosphorylated by p90RSK and Akt. Phosphorylation of Ser167 may confer tamoxifen resistance in breast cancer patients.Synonyms: ESR1, DKFZp686N23123, ER, ESR, ESRA, Era, NR3A1 , Estrogen Receptor alpha |
|---|
| Immunogen | Recombinant protein of human ESR1 |
|---|
| Other Names | ACTGP1|ACT1GP1|HY-psi-gamma-AC6|ER[b]2|ER[b]a|zfER[b]2|zfER-beta2|XER|era|esr|esra|nr3a1|ERbeta|xesr-1|ERalpha|xlERalpha1|xlERalpha2|LOC398733|LOC398734|2610524P08Rik|9130407C09Rik|AU019798|Era|M-ERA|MERA-S|MERA-W|ERA|ERAL1A|H-ERA|HERA-A|HERA-B|er|esr1|ER|ESR|ESRA|ESTRR|NR3A1|ER-alpha|Esr|RNESTROR|ERALPHA|ER[a]|eralpha|zfER[a]|ESR1|AA420328|AU041214|ERa|Estr|Estra|Nr3a1 |
|---|
| Gene, Accession # | Gene ID: 2099,13982,24890 |
|---|
| Catalog # | ABIN1514054 |
|---|
| Price | |
|---|
| Order / More Info | Estrogen Receptor 1 (ESR1) Antibody from ANTIBODIES-ONLINE GmbH |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|