| 产品详情 |
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| Product Name | KW 2478 |
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| Description | An Hsp90 inhibitor (IC50 = 3.8 nM for Hsp90α); inhibits the growth of OPM-2/GFP, KMS011, RPMI 8226, and NCI-H929 multiple myeloma cells (GI50s = 0.3, 0.34, 0.39, and 0.12 µM, respectively) and Raji, SR, and SC-1 non-Hodgkin's lymphoma cells (GI50s = 0.39, 0.098, and 0.33 µM, respectively); decreases expression of IGF-IRβ and c-RAF-1 and induces apoptosis in OPM-2/GFP and NCI-H929 cells; reduces IGF-IRβ, c-RAF-1, Cdk9, and phosphorylated ERK1/2 protein levels in tumor tissue and decreases tumor growth in an NCI-H929 mouse xenograft model at 100 mg/kg, |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | KW2478 Hsp-90 OPM2 KMS-011 RPMI8226 NCIH-929 NCIH929 SC1 IGFIRβ cRAF-1 cRAF1 Cdk-9 ERK-1 ERK-2 Hsp-90α 90-α |
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| Gene, Accession, CAS # | CAS: 819812-04-9 |
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| Catalog # | 22418-1 |
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| Price | |
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| Order / More Info | KW 2478 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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