| 产品详情 |
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| Product Name | KW 2449 |
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| Description | A potent multi-kinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase (IC50s = 6.6, 14, 4, and 48 nM, respectively); has growth inhibitory activity against leukemia cells expressing FLT3 with activating mutations (GI50s = 11-46 nM); suppresses phosphorylation of FLT3 and STAT5 in MOLM-13 cells in a dose-dependent manner in vitro; inhibits colony formation of human primary AML cells with wild-type or activated mutant FLT3; induces MOLM-13 xenograft regression in a dose-dependent manner in vivo |
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| Size | 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | KW2449 FLT-3 ABLT3151 Signal transducer activator transcription 5 MOLM13 STAT |
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| Gene, Accession, CAS # | CAS: 1000669-72-6 |
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| Catalog # | 22207-50 |
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| Price | |
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| Order / More Info | KW 2449 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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