| 产品详情 |
| Edit |   |
|---|
| Product Name | KW 2449 |
|---|
| Description | A potent multi-kinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase (IC50s = 6.6, 14, 4, and 48 nM, respectively); has growth inhibitory activity against leukemia cells expressing FLT3 with activating mutations (GI50s = 11-46 nM); suppresses phosphorylation of FLT3 and STAT5 in MOLM-13 cells in a dose-dependent manner in vitro; inhibits colony formation of human primary AML cells with wild-type or activated mutant FLT3; induces MOLM-13 xenograft regression in a dose-dependent manner in vivo |
|---|
| Size | 10 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | KW2449 FLT-3 ABLT3151 Signal transducer activator transcription 5 MOLM13 STAT |
|---|
| Gene, Accession, CAS # | CAS: 1000669-72-6 |
|---|
| Catalog # | 22207-10 |
|---|
| Price | |
|---|
| Order / More Info | KW 2449 from CAYMAN CHEMICAL COMPANY |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|