产品名称 CD45 Antibody from SICGEN ANTIBODIES
产品货号 AB0100-500
产品价格 现货询价,电话:010-67529703
产品规格 1.5 mg
产品品牌 SICGEN ANTIBODIES
产品概述
产品详情
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Antigenic SpecificityCD45
Clonepolyclonal
Host SpeciesGoat
Reactive Specieshuman, mouse, rat, bovine, canine, chicken/avian, donkey, feline, goat, guinea pig, hamster, horse, porcine, rabbit, sheep, simian, other
Isotypen/a
Formatimmunoaffinity purified
Size1.5 mg
Concentration3 mg/ml
ApplicationsWB
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DescriptionGoat polyclonal antibody to CD45. It is a 180-220 kDa type I transmembrane glycoprotein and a member of the protein tyrosine phosphatase (PTP) family. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. It is expressed in all hematopoietic cells, but highest on lymphocytes. PTPs are known to be signalling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. It has intrinsic tyrosine phosphatase activity and it is essential for T and B cell antigen receptor-mediated activation. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signalling. CD45 also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signalling. The cross-linking of CD45 induces apoptosis in lymphocytes. Using Jurkat cell lysate detects a band 180-220 kDa by Western blot.
ImmunogenPurified recombinant peptide derived from within residues 1,260 aa to the C-terminus of human CD45 produced in E. coli.
Other NamesB220, CD45 antigen, CD45R, GP180, L-CA, LCA, leukocyte common antigen, LY5, protein tyrosine phosphatase, PTPRC, receptor type c polypeptide, receptor-type tyrosine-protein phosphatase C, RP11-553K8.4, T200, T200 glycoprotein, T200 leukocyte common antigen
Gene, Accession #CD45, Gene ID: 5788
Catalog #AB0100-500
Price
Order / More InfoCD45 Antibody from SICGEN ANTIBODIES
Product Specific Referencesn/a
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