| 产品详情 |
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| Antigenic Specificity | SET7 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry: 1:500-1:2,000, Immunoprecipitation: 2-5 µg/mg lysate, Western Blot: 1:2,000-1:10,000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | SET7 Polyclonal Antibody. Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated tran |
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| Immunogen | n/a |
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| Other Names | Set7/9 |
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| Gene, Accession # | Entrez: 73251, 80854; Uniprot: Q8VHL1, Q8WTS6 |
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| Catalog # | A301-747A |
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| Price | |
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| Order / More Info | SET7 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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