产品名称 Neurofilament Marker Antibody from BIOLEGEND
产品货号 837904
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 BIOLEGEND
产品概述
产品详情
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Antigenic SpecificityNeurofilament Marker
CloneSMI 312
Host SpeciesMouse
Reactive Specieshuman, mouse, rat
IsotypeIgG1/ IgM
Formatpurified
Size100 µg
Concentrationn/a
ApplicationsIHC-P, Western Blot (WB), ICC, Immunofluorescence Microscopy (IF)
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DescriptionPurified anti-Neurofilament Marker (pan axonal, cocktail). Neurofilaments (NF) are approximately 10 nanometer intermediate filaments found in neurons. They are a major component of the neuronal cytoskeleton and their function is primarily to provide structural support for the axon and to regulate axon diameter. There are three major NF subunits, and the names given to these subunits are based upon the apparent molecular mass of the mammalian subunits on SDS-PAGE. The light or lowest (NF-L) runs at 68-70 kD, the medium or middle (NF-M) runs at about 145-160 kD, and the heavy or highest (NF-H) runs at 200-220 kD. However, the actual molecular weight of these proteins is considerably lower due to the highly charged C-terminal regions of the molecules. The level of NF gene expression correlates with the axonal diameter, which controls how fast electrical signals travel down the axon. Mutant mice with NF abnormalities have phenotypes resembling amyotrophic lateral sclerosis. NF immunostaining is common in diagnostic neuropathology. It is useful for differentiating neurons (positive for NF) from glia (negative for NF).
ImmunogenHomogenized hypothalami recovered from Fischer 344 rats.
Other NamesSMI-312, SMI312
Gene, Accession #Gene ID: 4747, 4744, 4741
Catalog #837904
Price
Order / More InfoNeurofilament Marker Antibody from BIOLEGEND
Product Specific ReferencesPubMed: 18794346
产品资料