| 产品详情 |
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| Product Name | PD 198306 |
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| Description | An orally bioavailable and potent inhibitor of MEK1/2 inhibitor (IC50 = 8 nM); selective for MEK1/2 over ERK, c-Src, PI3Kγ, and cyclin-dependent kinases (IC50s = >1 µM); reduces ERK1/2 phosphorylation and inhibits growth of HL-60 cells in vitro; reduces ERK1/2 phosphorylation and MMP-1 expression in a dose-dependent manner in a rabbit model of osteoarthritis when administered at doses ranging from 10-30 mg/kg; reduces ERK1/2 activity in the lumbar spinal cord and blocks static allodynia in rat models of streptozotocin- and chronic constriction injury-induced neuropathic pain, |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PD198306 MEK-1 2 ERK-1 2 HL60 MMP1 CSRC PI3K-γ MEK1 MEK2 CDK ERK1 ERK2 |
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| Gene, Accession, CAS # | CAS: 212631-61-3 |
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| Catalog # | 23966-5 |
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| Order / More Info | PD 198306 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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