产品详情 |
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Antigenic Specificity | A-Raf |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | purified |
Size | 250 µg |
Concentration | n/a |
Applications | Western Blot: 1 µg/mL |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | A-Raf Polyclonal Antibody. The RAF family of siganlling proteins has three isoforms: A RAF, RAF 1 and B RAF. These proteins are instrumental in forwarding the stimulus generated by mitogens from monomeric G proteins to the MAP kinase pathway. RAF 1 is known to be downstream of Ras and binds to it by an N terminal noncatalytic domain. This domain is conserved in A RAF and B RAF. 14-3-3 is also known to be an activator of RAFs. Activated RAF directly phosphorylates and activates MEK. A RAF is expressed at a very high concentration in urogenital and kidney tissues. |
Immunogen | n/a |
Other Names | RP1-230G1.1, A-RAF, ARAF1, PKS2, RAFA1 |
Gene, Accession # | Entrez: 11836, 369, 64363; Uniprot: P04627, P10398, P14056 |
Catalog # | PA1-21440 |
Price | |
Order / More Info | A-Raf Antibody from INVITROGEN ANTIBODIES |
Product Specific References | n/a |
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