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| Product Name | U0126 |
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| Description | Potent and selective non-competitive inhibitor of MAP kinase kinase. Inhibits MEK-1 and MEK-2 (IC50 values of 0.07 and 0.06 μM respectively) with little or no effect on the activities of PKC, Abl, Raf, MEKK, ERK, JNK, MKK-3, MKK-4/SEK, MKK-6, Cdk2 or Cdk4. Brain penetrant. Helps maintain human pluripotent stem cells in undifferentiated state. Available as part of the MAPK Cascade Inhibitor Tocriset™ and MAPK Inhibitor Tocriset™. Negative Control also available.. MW (observed): 380.48. |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1,4-Diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene |
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| Gene, Accession, CAS # | CAS: 109511-58-2 |
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| Catalog # | 1144/5 |
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| Order / More Info | U0126 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 11454659, 12794003, 14749443, 15056716, 15152046, 15257286, 16086034, 16627622, 16672661, 17018141, 17160007, 17494631, 17611287, 17715342, 18295207, 18400051, 18815127, 19193899, 19276383, 19298529, 19440492, 19501068, 19547699, 19666830, 19675232, 19723763, 19788733, 19846725, 20144602, 20154358, 20412391, 20427666, 20429916, 20448669, 20471392, 20505744, 20554871, 20685979, 20855151, 21068317, 21143600, 21195749, 21228181, 21247487, 21685895, 21829588, 21859479, 21936900, 21945811, 21994479, 21995440, 22003401, 22010199, 22114332, 22129063, 22273495, 22784513, 22833676, 22922731, 22949700, 22951829, 22975404, 23071303, 23226337, 23235157, 23332156, 23339737, 23373701, 23390529, 23497702, 23518767, 23607966, 23616561, 23675235, 23699517, 23749147, 23755184, 23898828, 23950932, 24401275, 24555435, 24567337, 24684682, 24736410, 24747967, 24908484, 24977707, 25030704, 25052197, 25137150, 25263555, 25324750, 25341622, 25479176, 25479966, 25600268, 25644401, 25653381, 25712213, 25999956, 26023933, 26065826, 26100015, 26116509, 26251761, 26620707, 26733817, 26780950, 26818516, 26888925, 27089465, 27150562, 28442401, 28445734 |
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