| 产品详情 |
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| Product Name | GSK 2830371 |
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| Description | Potent and selective allosteric inhibitor of Wip1 phosphatase (IC50 = 6 nM). Exhibits selectivity for Wip1 over 21 other phosphatases. Increases phosphorylation of Wip1 substrates, including p53, Chk2, H2AX and ATM. Attenuates tumor cell growth in a variety of lymphoid cell lines. Also inhibits lymphoma xenograft growth in vivo. Potentiates growth inhibitory effects of MDM2 inhibition in cancer cell lines in a p53-dependent manner. Orally bioavailable. Purity 98%. MW (observed): 461.02 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cycloprpylamino)-2-oxoethyl]-2-thiophenecarboxamide |
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| Gene, Accession, CAS # | CAS: 1404456-53-6 |
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| Catalog # | 5140/10 |
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| Price | |
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| Order / More Info | GSK 2830371 from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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| 产品资料 |
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