| 产品详情 |
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| Product Name | GSK 2334470 |
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| Description | Potent 3-phosphoinositide-dependent protein kinase (PDPK1) inhibitor (IC50 ~ 10 nM). Exhibits no effect on other kinases including Aurora, ROCK, p38 MAPK and PI 3-K. Suppresses T-loop phosphorylation and subsequent activation of PDK1 substrates S6K1, SGK and RSK in vitro; exhibits limited inhibitory effect on Akt activation. Delays melanomagenesis and metastasis in BrafV600E::Pten(-/-) mice. Purity 98%. MW (observed): 462.59 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide |
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| Gene, Accession, CAS # | CAS: 1227911-45-6 |
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| Catalog # | 4143/10 |
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| Order / More Info | GSK 2334470 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 24762669, 25446031, 26421002 |
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| 产品资料 |
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