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| Product Name | Bafilomycin A1 |
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| Description | Highly potent, selective inhibitor of vacuolar H+-ATPases (IC50 = 0.6 - 1.5 nM in bovine chromaffin granules). Selective for v-ATPase over other ATP hydrolyzing enzymes such as F-ATPases and the H+/K+-ATPase (P-ATPase). Thought to inhibit autophagy either by blocking autophagosome-lysosome fusion (in H4IIE cells), or by blocking lysosomal degradation. Purity 98%. MW (observed): 622.84 |
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| Size | 10 ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one |
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| Gene, Accession, CAS # | CAS: 88899-55-2 |
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| Catalog # | 1334/10U |
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| Price | |
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| Order / More Info | Bafilomycin A1 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 19057677, 19403749, 19812190, 21576371, 21604257, 21841793, 22069707, 22498477, 22647537, 22939285, 23291478, 23741498, 23800949, 23937156, 24666643, 24763050, 24849359, 25086775, 25301941, 25367116, 25385822, 25480788, 25642769, 25768340, 25919711, 26029847, 26101220, 26339598, 26757825, 27341800, 27351204, 27769052, 28296541, 28613987, 29162859 |
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