产品名称 FOXP3 Antibody from BIOLEGEND
产品货号 320202
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 BIOLEGEND
产品概述
产品详情
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Antigenic SpecificityFOXP3
Clone259D
Host SpeciesMouse
Reactive Specieshuman, cross-reactivity: cynomolgus, rhesus, baboon, chimpanzee
IsotypeIgG1, κ
Formatpurified
Size100 µg
Concentrationn/a
ApplicationsWestern Blot (WB), IHC, Intracellular Staining for Flow Cytometry (ICFC)
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DescriptionPurified anti-human FOXP3. FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in scurfy mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2. The 259D antibody recognizes human FOXP3 epitope in the region of amino acids 105-235.
ImmunogenFull-length FOXP3 protein
Other NamesForkhead box protein P3, Scurfin, JM2, IPEX, Zinc finger protein JM2
Gene, Accession #Gene ID: 50943
Catalog #320202
Price
Order / More InfoFOXP3 Antibody from BIOLEGEND
Product Specific ReferencesPubMed: 16403912,16617117,16732291,17644734,18313267,18981295,19180473,19875613,24610777,24943216,24947990
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